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Although the events that lead from IOP elevations to ganglion cell damage are not well defined, a body of recent work has pointed at mechanotransducing TRPV4, piezo and TREK-1 channels and immune mechanisms as key pressure targets in trabecular meshwork, ciliary body, retinal ganglion, endothelial cells and glia

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doi: 10.1016/j.phrs.2022.106361 32 TsikasD